Promethazine HCl and Codeine Phosphate Oral Answer must be utilised with warning in sufferers with impairment of hepatic purpose, and individuals must be monitored carefully for respiratory melancholy, sedation, and hypotension.

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Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Solution really should not be increased if cough fails to reply; an unresponsive cough really should be reevaluated in 5 days or faster for achievable underlying pathology, like overseas entire body or reduce respiratory tract disease [see Dosage and Administration (two.three)].

Because of the danger of respiratory despair, avoid using opioid antitussives, which include Promethazine HCl and Codeine Phosphate Oral Remedy in sufferers with compromised respiratory operate, patients at risk of respiratory failure, and in aged, cachectic, or debilitated individuals.

Such as, numerous documented instances of Demise happened during the post-operative time period adhering to tonsillectomy and/or adenoidectomy, and a lot of of the kids had evidence of being ultra-quick metabolizers of codeine. Furthermore, small children with obstructive slumber apnea who are addressed with codeine for publish-tonsillectomy and/or adenoidectomy ache may very well be significantly delicate to its respiratory depressant result. Due to the chance of life-threatening respiratory melancholy and Loss of life:

Contact regional point out Qualified licensing board or condition controlled substances authority for info on how to prevent and detect abuse or diversion of the merchandise.

Outcomes around the Cardiovascular System Codeine creates peripheral vasodilation which can cause orthostatic hypotension or syncope. Manifestations of histamine release and/or peripheral vasodilation might include things like pruritus, flushing, crimson eyes and sweating and/or orthostatic hypotension.

Stimulation may be apparent, specifically in little ones and geriatric patients. Convulsions may possibly hardly ever take place. A paradoxical response has been reported in little ones acquiring one doses of seventy five mg to a hundred twenty five mg orally, characterized by hyperexcitability and nightmares.

Thought really should be offered on the discontinuation of promethazine HCl and to the use of other prescription drugs if these reactions arise. Respiratory melancholy, nightmares, delirium, and agitated conduct have also been claimed in A few of these sufferers.

Know the signs of the overdose, like difficulties breathing, remaining unusually fatigued or sleepy, or not having the ability to answer or get up. Make sure you inform caregivers and shut contacts where by it is saved. Be certain they learn how to utilize it. Just after naloxone is offered, you must get emergency assistance without delay. Naloxone is A short lived remedy. Repeat doses might be needed.

It is actually soluble in water and freely soluble in Alcoholic beverages. The molecular excess weight is 320.88. Its molecular formula is C17H20N2S•HCl, and it has the subsequent chemical structure.

This medicine is taken only when wanted, so there isn't any Exclusive Recommendations to get a missed dose. Dosing The dose of this medicine are going to be unique for different people. Abide by your medical doctor's orders or maybe the directions on the label. The subsequent info involves only the typical doses of the medication. If the dose differs, will not transform it Except your health practitioner informs you to take action.

1)]. All sufferers treated with opioids have to have careful checking for signs of abuse and habit, due to the fact utilization of opioid analgesic and antitussive merchandise carries the risk of dependancy Promethazine codeine syrup even under suitable healthcare use.

Negative desires blurred or loss of vision confusion concerning time, location, or individual continuing ringing or buzzing or other unexplained sound while in the ears problems getting a bowel movement disturbed shade notion double eyesight drowsiness false or strange sense of well-getting halos about lights hearing reduction holding Fake beliefs that can't be adjusted by point increased sensitivity of your pores and skin to sunlight evening blindness overbright appearance of lights redness or other discoloration in the skin calm and quiet sensation severe sunburn sleepiness difficulties sleeping tunnel eyesight abnormal excitement, nervousness, or restlessness vomiting Other Negative effects not shown could also arise in certain people. In the event you recognize another effects, Examine together with your healthcare Expert.